Abstract: Modified mycotoxins are a group of important risk factors of food safety,which are characterized by high toxicity,large variety and great differences in chemical structure as well as physical and chemical properties. In this paper,the formation and variety of modified mycotoxins were reviewed. And characteristics and rules of its toxicity were analyzed. The advantages,disadvantages and application of different extraction methods,cleanup ways and determination techniques were discussed in the process of simultaneous determination multi-toxins. Finally,this paper expected the pollution,toxicology characteristic,and metabolism of modified mycotoxins,aiming to supply theoretical reference for better assessment exposure levels of modified mycotoxins in food and the safety of our food.