Abstract: To study the protective effects of naturally fermented camel milk on acute alcoholic liver injury in mice. 24 male SPF CD-1 (ICR) mice were randomly divided into 3 groups,the normal control group,model control group,and naturally fermented camel milk group. After a two week administration,the acute alcohol liver injury mouse model was set up by intragastric administration of alcohol in the dose of 7.3 g/kg. Body weight,liver index,serum and liver biochemical indicators were measured in each group.The pathologicalchanges of liver were observed by light microscope with HE staining. The result showed that,compared with the control group,activities of serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),and proinflammatory cytokines contents of serum in the model group were significantly increased (p<0.05 or p<0.01). The liver histopathological sections also showed significant injury and extensive inflammatory cell infiltration. Compared with the model group,the ALT activities of the naturally fermented camel milk group decreased significantly (p<0.05),and the contents of tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β) decreased significantly (p<0.01). The results of HE staining showed that the inflammatory cell infiltration in the liver tissue was significantly reduced,and the degree of steatosis was reduced. The contents of malondialdehyde (MDA) in the liver of naturally fermented camel milk group was significantly decreased (p<0.05),the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) was significantly increased (p<0.05),and the contents of TG was significantly lower than that of the model group (p<0.01).The results show that naturally fermented camel milk has a good protective effect on acute alcoholic liver injury in mice,which exert its beneficial effects mainly through reducing the contents of inflammatory response in body and improving the oxidative stress in the liver of mice.