Abstract: Objective:The role of pea oligopeptides in relieveing insulin resistance of hepatic cells was investigated. Methods:Insulin-resitant HepG2 cell model was induced by high concentration of insulin,GOP-POD assay was used to detect the consumption of glucose before and after insulin inducing. The cellular proliferation was measured by MTT assay. The expression of InsR protein and Caspase-3 were determined by flow cytometry(FCM). Results:The glucose consumption decreased by 10% after inducing by insulin in HepG2/IR cells. Different concentrations of pea oligopeptides were added to the process of HepG2/IR cell formation. And the consumption glucose of cell was 1.31~1.68 times higher than that of HepG2/IR model,while the expression of InsR was increased by 1.19~1.34 folds,and the expression of Caspase-3 increased. Conclusion:Pea oligopeptides had a certain effect in relieving the formation of insulin resistance in hepatocytes.