Abstract: Due to the excellent stability and surfactivity of perfluorinated compounds,they have been used in many fields. However,they are a kind of environmental pollutants with multiple organ toxicity,which have the characteristics of persistence,bioaccumulation and hard degradation. The article mainly summarizes the harm of perfluorinated compounds such as perfluorooctanoic acid and perfluorooctane sulfonate,the domestic and international restrictions and regulations on them. The contamination levels of perfluorinated compounds in different kinds of food were also reviewed. The recent research progress on determination technology of perfluorinated compounds in food was introduced. The advantages and disadvantages of different determination methods are compared emphatically,and the development direction of detection technology in the future is expounded. The article would provide references for the risk assessment and studies on perfluorinated compounds in food.