Abstract: Vibriosis is the major disease of aquatic products, while Vibrio harveyi is one of the major marine pathogens discovered in recent years in the world, has repeatedly caused epidemic diseases of aquatic products, causing huge economic losses.The main pathogenic mechanism and detection technology of Vibrio harveyi and concludes the research progress on the prevention and treatment of Vibrio harveyi disease were summarized.The main cause of host disease caused by Vibrio harveyi was hemolysin (vhh), extracellular protease, iron carrier, etc. in the extracellular product secreted by Vibrio harveyi. Vibrio itself had resistance to host serum clearance. And environmental factors such as water temperature, as well as the flora density sensing system. The research progress on the prevention and treatment of Vibrio harveyi disease detection were summarized, and provide an effectived reference for better research and prevention of marine Vibrio disease in the future.