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中国精品科技期刊2020
周婷, 余彩英, 吴卫, 奉建芳. 均匀设计法优化葛根素白蛋白微球处方工艺[J]. 食品工业科技, 2019, 40(4): 141-145. DOI: 10.13386/j.issn1002-0306.2019.04.023
引用本文: 周婷, 余彩英, 吴卫, 奉建芳. 均匀设计法优化葛根素白蛋白微球处方工艺[J]. 食品工业科技, 2019, 40(4): 141-145. DOI: 10.13386/j.issn1002-0306.2019.04.023
ZHOU Ting, YU Cai-ying, WU Wei, FENG Jian-fang. Optimised Formulation of Puerarin Albumin Microsphere by Uniform Design[J]. Science and Technology of Food Industry, 2019, 40(4): 141-145. DOI: 10.13386/j.issn1002-0306.2019.04.023
Citation: ZHOU Ting, YU Cai-ying, WU Wei, FENG Jian-fang. Optimised Formulation of Puerarin Albumin Microsphere by Uniform Design[J]. Science and Technology of Food Industry, 2019, 40(4): 141-145. DOI: 10.13386/j.issn1002-0306.2019.04.023

均匀设计法优化葛根素白蛋白微球处方工艺

Optimised Formulation of Puerarin Albumin Microsphere by Uniform Design

  • 摘要: 为优化葛根素白蛋白微球处方工艺。以牛血清白蛋白为载体,采用乳化热固化法制备葛根素白蛋白微球。以包封率和载药量为综合评价指标,以牛血清白蛋白用量、葛根素用量、司盘80用量为考察因素,在单因素实验的基础上,利用均匀设计法优化葛根素白蛋白微球的处方工艺。葛根素白蛋白微球最优处方为:牛血清白蛋白0.20 g,葛根素30.00 mg,司盘80为0.80 mL,验证处方的包封率为76.75%±2.09%,载药量为9.81%±0.14%。采用均匀设计优化法制备的葛根素白蛋白微球综合评分高,模型预测性良好。

     

    Abstract: To optimize the formulation of puerarin albumin microspheres. The microspheres were prepared by emulsion-heat stabilization techniques using albumin as carrier. The encapsulation efficiency and drug loading rate of the puerarin albumin microspheres were selected as comprehensive evaluation indexes. The amount of bovine serum albumin, the amount of puerarin and the amount of span-80 were selected as factors.Uniform design method were used to optimize the formulation process of puerarin albumin microspheres. Optimum formulation of puerarin albumin microspheres was as follows:Bovine serum albumin was 0.20 g, puerarin was 30.00 mg, span-80 was 0.80 mL. The entrapment efficiency of optimum formulation was 76.75%±2.09% and the drug loading was 9.81%±0.14%. The formulation process of the puerarin albumin microspheres optimized by uniform design method was effective and feasible with a good prediction, and the results showed a high comprehensive score.

     

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