Abstract: Response surface analysis was proposed to optimize the heat reflux extraction process of lignans fromthe leaves of Cinnamomum camphora. The effects of ethanol concentration,solid-liquid ratio,time,reflux times and temperature on lignans yield were investigated by single factor experiments. Based on the single factor level determination,the Box-Behnken center combination method was applied to determine the optimization of the extraction. Results showed that the optimum extraction condition were as follows:Ethanol concentration 87%,solid-liquid ratio 1:11 g/mL,reflux times 3,the temperature 70℃. Under the optimizatiom conditions,the experiment yield of lignans was(43.39±4.91) mg/g,which had less cleviation with the predicted value(44.27 mg/g). The results demonstrated that it was practicable to optimize the heat reflux extraction process using response surface methodology.