Abstract: In order to research the effects of ethylene and 1-MCP on post-harvest active oxygen metabolism of melon, on the basis of existing research, the Boxiekexin melon was sprayed with 500 mg/L ethylene, the 1-MCP treatment group melon was fumigated with 2 μL/L 1-MCP for 24 h, and then stored at 7℃. The O₂^- production rate, MDA content and active oxygen metabolism related enzyme activity were measured every 24 h. The results showed that, the O₂^- production rate in the melon fruit of the ethylene treatment group was higher than the control at 3~9 d, MDA content was higher than the control at 0~9 d. The O₂^- production rate and MDA content in the melon fruit of the 1-MCP treatment group were lower than the control group during the storage period. The activity of active oxygen metabolism related enzymes such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), ascorbate peroxidase (APX), polyphenol oxidase (PPO) in the ethylene treatment group were lower than the control, and the activity of CAT, POD, APX reached the peak on the 4th day which were 17.42%, 29.61% and 3.25% lower than the control group. The CAT and SOD activity in the melon fruit of the 1-MCP treatment group were higher than the control at 3~9 d. POD, APX activity reached its peak on the 4th day, which were 36.50% and 18.97% higher than the control group respectively. The results indicated that ethylene and 1-MCP played an important role in regulating of postharvest senescence of Boxiekexin melon.