Abstract: With a strong ability of protein hydrolysis and many probiotic functions, Lactobacillus helveticus has become a hot spot in research of probiotic bacteria. In this paper, probiotic activities of hydrolyzed peptides originated in L.helveticus fermented milk and the related proteolytic system of L.helveticus, probiotic activities of extracellular polysaccharides produced by L.helveticus and probiotic activities of L.helveticus strains were reviewed. At last, the research progress and new applications of L.helveticus in cheese fermentation were also summarized.Many studies have indicated that Lactobacillus is a kind of probiotics with broad application prospects.