Abstract: The bioconcentration characteristics of cadmium( Ⅱ) with different concentrations( Cd²⁺,0,16,32,48,64 and 80 mg / L) by Boletus edulis under liquid fermentation were investigated.The results showed that the treatment with increasing Cd²⁺concentrations significantly inhibited mycelia growth( p < 0.05),and 50% inhibitory concentration was 56 mg / L.Mycelia showed significant accumulation capacity for Cd²⁺,with the highest content of3335.7 mg Cd per kg mycelia( DW),and the bioconcentration factor was 52.1( p < 0.05). The contents of total soluble sugars and polysaccharides in mycelia were increased firstly and then decreased with increasing Cd²⁺concentrations.The content of polysaccharides in mycelia treated with Cd²⁺significantly higher than that of control( p < 0.05). Soluble protein contents were decreased firstly and then increased with increasing Cd²⁺concentrations,with the peak at 80 mg / L Cd²⁺( p < 0.05). The activities of CAT and SOD were significantly increased by lower Cd²⁺concentrations but inhibited by high Cd²⁺concentrations( p < 0.05).The activities of POD were significantly inhibited by Cd²⁺treatment( p < 0.05).