Abstract: Objective:The aim of this investigation was to develop a method to detect methanol quantitatively in self-made wine. Methods :Using gas chromatography for quantitative detection of methanol in wine. The chromatographic conditions :stationary phase was capillary column of Gs BP-Ino WAX,column temperature :90 ℃,carrier gas:nitrogen,flow rate:1.4 m L/min;hydrogen flame ionization detector(FID) as the detector,the temperature was 200 ℃;the inlet temperature was 150 ℃. Results:The data showed that in the concentration range of 16 ~ 1000 μg / m L, a good linear relationship( R2= 0. 9987). The method was validated with a good accuracy and the relative standard deviation( RSD) was 1. 2 %. Recovery was between 90. 03 % ~ 94. 00 %.Conclusion : Quick and relatively low- cost method was developed, and the method was appropriate for quantitative analysis of methanol in self-made wine.