Abstract: In order to purify of total falconoids in Litchi Pericarp,the Litchi Pericarp extraction was obtained by inner boiling method. And the purification research of the Litchi Pericarp extraction was carried out by macroporous resin,The results showed that the best macroporous resin was AB-8 to purify total flavonoids in Litchi Pericarp. And the optimal purification process of sample concentration was 0.5 mg/m L,the amount was24.0 m L;the adsorption velocity of 1 m L/min,the elution concentration of 80% ethanol solution,and the elution volume was 30.0 m L,the elution flow rate was 1 m L/min. Under the process conditions,the adsorption amount of flavonoids from Litchi Pericarp was 5.18 mg/g,the desorption rate was 99.0%,the content of total flavonoids in Litchi Pericarp increased from 31.4% to 82.7%. The recovery rate of total flavonoids as 92.1%. AB-8macroporous resin purified extractions by inner ebullition method could effectively improve the purification effect was good. And the resin was recovered and utilized more convenient.