Abstract: The effect of calcium citrate malate( CCM),calcium carbonate( Ca CO3),and bone calcium( BC) added ferrous fumarate( FF) on the absorption of ferrum,calcium were investigated,respectively.By iron deficiency animal model,the concentrations of serum ferrum( SFe) and hemoglobin( Hb) were determined as well as the pharmacokinetic curve of calcitonin( CT) for the three groups in rats.The results showed that the concentrations of Hb were increased significantly by CCM / FF treatments only after 3 days.Furthermore,the concentrations of Hb and SFe by CCM / FF treatments were significantly higher than those by Ca CO3/ FF treatments after 14 days and 1 day,respectively( p < 0.01). These results indicated that CCM had less inhibition on Fe absorption compared with Ca CO3.In addition,compared with Ca CO3 and BC treatments,the CCM treatment had the highest AUC of the calcitonin,which implied that CCM was better in bioavailability than Ca CO3 and BC.