Abstract: Objective: To evaluate and compare the hyperglycemic effect of Zhejiangqiye and Shanmeierhao pumpkin on alloxan induced diabetes mice in vivo. Methods: Diabetes mice were established through the tail injection of alloxan.After gavaged for 7 days,postprandial blood glucose and fasting blood glucose,insulin,TG,Tch and MDA contents,SOD activity of serum and the liver glycogen contents were analyzed.Results: Two kinds of pumpkins all had certain therapeutic effect on alloxan diabetic mice.All the extracts could decreased the contents of fasting blood glucose and MDA,and increased the contents of insulin,hepatic glycogen and TG,as well as the level of SOD activity,but the effect on postprandial blood glucose levels and TC contents were not significant.Zhejiangqiye and Shanmeierhao pumpkin extracts had different influence on different indices,the Zhejiangqiye had stronger effect on the fasting glucose,glycogen,SOD and MDA,but the effect on TG and insulin were showed different.The mechanism of pumpkins' antidiabetic effect was likely to be through repair the injured β cells of pancreatic to get it restored to normal or through promote glycogen synthesis to improve the glucose utilization.And the regulation of glucose utilization also had certain associated with the antidiabetic effect.