Abstract: To investigate theraputic effect of different concentration ethanol extracts( 0%,25%,50%,75%) of Sargassum integerrimum against hyperuricemia induced by model mouse established by oral lavage yeast extract,the uric acid content in serum,activities of xanthine oxidase( XOD) and adenosine deaminase( ADA) in liver,indexes of liver and kidney,histopathology of kidney were measured.Results showed that mouse exposed to yeast extract presented higher content of uric acid and activities of XOD and ADA( p < 0.01) than normal mouse.The content of uric acid and activities of XOD and ADA were reduced by different concentration ethanol extracts,and the content of uric acid were remarkably weakened by 50% ethanol extract.Also the histopathology in kidney was observed to restore to normal conditions in ethanol extract- treated mouse. Overall,ethanol extract from Sargassum integerrimum exhibited an obviously positive effect on mouse of hyperuricemia,which was connected with uric acid metabolism.