Abstract: Objective:To investigate the effects of wheat peptide on skeletal muscle protein metabolism in rats during simulated altitude training and its mechanism. Methods:75 male SD rats were randomly divided into normal control group(group A),hypoxia group(group B),exercise training group(group C),hypoxic exercise training group(group D),hypoxic exercise training + add wheat peptide group(group E),each group had 15 rats. Rats in group C,group D and group E were undergoing no load swimming for 9 weeks. Rats in group E were fed wheat peptide solution after each train. After the experiment,the skeletal muscle total protein(Pro),myosin(Myo) and insulin-like growth factor-1(IGF-1) were detected. Results:Compared with group A,the total protein(Pro) and myosin(Myo) of rat skeletal muscle in group B were significantly reduced,and the Pro in group C showed no difference,while Myo content was significantly reduced. The Pro and Myo contents in skeletal muscle of rats in group E were higher than hypoxic control group and exercise training group. Compared with group A,the insulin growth factor-l(IGF-1) levels in rat skeletal muscle and serum in group B and group C were reduced. The IGF-1 levels in rat skeletal muscle and serum in group E were higher than group B and group C. Conclusion:Supplying of wheat peptide in rats could effectively reduce the effect of simulated altitude training on skeletal muscle protein. It might promote the secretion of IGF-1 to accelerate the anabolism of skeletal muscle protein.