Abstract: Compared with the substrate decrease, saccharifying power, esterifying power, protein enzyme activities and total acid of different Monascus Yaoqu (a new kind of rice-koji which had been added traditional Chinese medicinal herb) . The experimental selected the best of materials, included Panax quinquefolium and Rhodiola, also found the optimal ratio and processing ways that Panax quinquefolium powder was 0.6% at most, Rhodiola extract was between 0.6% and 4.8%. Sake-making was by this Monascus Yaoqu, and the physical and chemical indexes, antioxidant activity of Sake were better than the rice-koji Sake.