Abstract: Ochratoxin A (OTA) is a toxic secondary metabolite produced by fungi, and it is always detected in grape and its products. This paper mainly reviewed the measures that controlling OTA in grape and its products, which contained two aspects, the inhibition of OTA-producing fungi and the elimination of OTA.Aspergillus and Penicillium were the two main pathogens in grape, among which Aspergillus carbonarius was the most dominant one. By simulating the growth of grape and manufacture of grape products, it was proved that temperature, slight and humidity were the three important factors that affected the growth of fungi and production of OTA. There were three methods removing OTA, namely, physical method, chemical method and biological method, among which biological method was the current research hot spot.