Abstract: Anti-hypoxia and anti-fatigue effects of water extracts from pummel pericarp were observed in this experiment. Mice were randomly divided into four groups:normal control, pummel pericarp water extracts lowdose group, medium-dose and high-dose group, and given corresponding solution intragastrically for 10 d.Hypoxia tolerance under decapitation or normal pressure and loaded swimming test were conducted to observe the gasping duration after decapitation, survival time in normal pressure anoxia and swimming endurance. Results revealed that water extracts from pummel pericarp at 1g/mL and 2g/mL could significantly prolonged gasping duration after decapitation and survival time in normal pressure anoxia (p<0.01) , improved swimming endurance (p<0.05 and p<0.01 respectively) , increased liver glycogen and muscle glycogen content (p<0.01) . Water extracts from pummel pericarp exhibited excellent effects on improving hypoxia and fatigue resistance.