Abstract: Konjac glucommanan (KGM) -Methylcellulose (MC) film were prepared, and the effect of MC content, glycerol content, homogeneous time and drying temperature on the film were also evaluated. Firstly, single factors experiments were carried out, and the factor was MC content, glycerol content, homogeneous time and drying temperature respectively. These properties of film were determined by water vapor permeability (WVP) , elongation at break (E) and tensile strength (TS) . Response surface analysis test were used, and WVP and E were choosed as response values. WVP was 8.4511×10-10g/m·s·Pa, when that glycerol content 0.963% (V/V) , MC content0.238% (W/V) , drying temperature 59.6℃ and homogeneous time 8.91 min. E was 130.25%, when that glycerol content 0.985% (V/V) , MC content 0.363% (W/V) , drying temperature 30℃ and homogeneous time 7.68 min.