Abstract: Chrysanthemum Morifolium Ramat ( CMR) was extracted with water by ultrasonic- microwave synergistic method.The effect of solid- liquid ratio, microwave power and extraction time on the extraction yield of total flavonoids, chlorogenic acid and solid content of CMR water extract was studied.The optimal extraction conditions were determined through single-factor and orthogonal experiments as follows: microwave power 250W, extraction time 240s, and solid- liquid ratio 1 ∶ 30. Under above conditions, the extraction yield of total flavonoids reached62.20mg /g, while chlorogenic acid and solid content reached 4.05mg /g and 50.75% respectively. Compared with traditional water extraction methods and lately new methods, ultrasonic or microwave method, the method studied in this paper has the advantages of low solvent usage and high efficiency.