Abstract: On March 10 th, 2013, the State Council institutional reform and function transformation program was released.Related food safety administration functions of Food Safety Committee Office of State Council, State Food and Drug Administration, General Administration of Quality Supervision, Inspection and Quarantine, and the State Administration for Industry &Commerce were integrated into the newly founded China Food and Drug Administration ( CFDA for short) .On March 31 st, CFDA issued Main duties and responsibilities, internal institutions and staffing requirements of CFDA ( “Three provisions”for short) .These reforms will directly affect many aspects of food enterprises.How much a food enterprise can benefit from the super-ministries reform, not only depends on the strength of execution, but more depends on how the enterprise to adapt to the reform. In this paper, measurements of super ministry system reform and the “Three provisions”of CFDA, as well as insufficiency and improvement in food safety supervision were discussed.Opportunities and challenges the super-ministries reform brings to food production enterprises were also analyzed in details.