Abstract: Lycopene is a kind of natural active substance in tomato and other red fruits, which is one of the most important meal of antioxidant nutrients, due to good color and a plurality of conjugated carbon-carbon double bond structure, has caused extensive concern of plants, agricultural and nutritional science. Studies showed that lycopene had obvious role in anti-oxidation , anti-cancer , prevention of cardiovascular diseases and neurodegenerative diseases, which had become a hot spot research in the international functional food. This paper would make a further review on its biological activity.