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中国精品科技期刊2020
马茜, 慕家琪, 杨遂群, 喻乐乐, 张自萍. 贺兰山紫蘑提取物对H22小鼠抗氧化能力的影响[J]. 食品工业科技, 2013, (14): 342-345. DOI: 10.13386/j.issn1002-0306.2013.14.019
引用本文: 马茜, 慕家琪, 杨遂群, 喻乐乐, 张自萍. 贺兰山紫蘑提取物对H22小鼠抗氧化能力的影响[J]. 食品工业科技, 2013, (14): 342-345. DOI: 10.13386/j.issn1002-0306.2013.14.019
Effect of the extract from cortinarius rufo-olivaceus on antioxidation activities in H22 tumor bearing mouse[J]. Science and Technology of Food Industry, 2013, (14): 342-345. DOI: 10.13386/j.issn1002-0306.2013.14.019
Citation: Effect of the extract from cortinarius rufo-olivaceus on antioxidation activities in H22 tumor bearing mouse[J]. Science and Technology of Food Industry, 2013, (14): 342-345. DOI: 10.13386/j.issn1002-0306.2013.14.019

贺兰山紫蘑提取物对H22小鼠抗氧化能力的影响

Effect of the extract from cortinarius rufo-olivaceus on antioxidation activities in H22 tumor bearing mouse

  • 摘要: 通过研究贺兰山紫蘑不同提取物对H22荷瘤小鼠体内抗氧化酶系统的影响,探讨其可能的抗肿瘤机制。给予紫蘑石油醚、乙酸乙酯、正丁醇提取物、紫蘑粗多糖、阳性对照香菇多糖灌胃及氟尿嘧啶腹腔注射后,采用比色法分别测定小鼠肝组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)的活性。结果表明,与阳性对照相比,紫蘑提取物均可不同程度提高荷瘤小鼠SOD、CAT、GSH-Px的活性,降低MDA含量,其中尤以乙酸乙酯部位和紫蘑粗多糖最为显著,说明贺兰山紫蘑可通过提高荷瘤小鼠抗氧化酶系统的活力,发挥其抗肿瘤机制。 

     

    Abstract: To study the antioxidation activities of the different extract from cortinarius rufo-olivaceus via H22-bearing mice, discussed the possible mechanism of anti-tumor.The colorimetric analysis was adopted to determine the level of superoxide dismutase (SOD) , malondialdehyde (MDA) , calalase (CAT) and glutathione peroxidase (GSH-Px) in liver of H22-bearing mice after by giving petroleum ether, ethyl acetate, butanol phase extractions.Different extractions from corinairus rufo-olivaceus could increase the activities of SOD, MDA, CAT, GSH-Px and decrease the level of MDA especially the ethyl acetate part and polysaccharide.The result showed that the extract of corinairus rufo-olivaceus could obviously enhance the antioxidant acticity and prevent lipid peroxidation damage in H22-bearing mouse.

     

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