Abstract: Chicken feet peeling (CFP) is the peeled skin after scalding in hot water during chicken processing.To make good use of the large amount of the CFP, the way of alkali to extract protein of CFP was applied. The total CFP protein extraction rate was deemed as indicator, different four factors were studied and then combined with the response surface method analysis. The result showed that optimum conditions were extraction temperature 63℃, extraction time 6.3h, alkali concentration 1.5%, and liquid-material ratio 41∶1 (mL/g) . The contribution rate of factors could be obtained by the F test was extraction temperature>extraction time>alkali concentration>liquid-material ratio. The verification experiment indicated that the eventually yield of the CFP protein was 81.7821%.