Abstract: Objective:To study the influence of the phragmites polysaccharide of cadmium poisoning in mice liver and kidney damage. Methods:Through the establishment of the mouse model of cadmium poisoning, respectively, to the high dose group of phragmites polysaccharide 480mg/ (kg·d) , polysaccharide medium dose group 240mg/ (kg·d) , polysaccharides low dose group 120mg/ (kg·d) , a total of intragastric adminstration for 20d. Normal group and model group of normal mice fed normal drinking water. Observing characterization of changes in weighing, paraffin slice with pathological morphological observation, detecting liver and kidney tissue content of MDA, GSH, GSH -Px activity. Results:The phragmites polysaccharides of different concentrations had a protective effect on mouse liver and kidney injury caused by cadmium poisoning. The high dose group of phragmites polysaccharide had the most effective tissue damage in mice protective effect. Conclusion: Phragmites polysaccharide had a protective effect on cadmium poisoning in mice liver and kidney damage.