Abstract: In order to provide the basis for the deep processing of Antarctic krill, response surface methodology (RSM) was used to optimize extraction parameters to astaxanthin from Antarctic krill shell. Based on the single -factor experiment, three variables, such as ratio of krill shell wet weight to dichloromethane, extraction temperature and extraction time, were optimized. The results showed that the ratio of krill shell wet weight to dichloromethane at 1∶ 5g/mL, shook at the constant temperature (30℃) for 7h, and extracted for 2 times, the extraction volume of astaxanthin achieve the maximum (131. 56μg/g) .