Abstract: Polysaccharides are one of the most important natural bioactive ingredients in pumpkin. Pumpkin polysaccharides have variable structure and complex monosaccharide composition, and possess a variety of biological activities such as hypoglycemia and antioxidant. In recent years, with the increasing incidence of diabetes, the hypoglycemic effect of pumpkin polysaccharides has attracted more and more attentions of scholars. The research focuses on the structure, monosaccharide composition and different mechanism of action of pumpkin polysaccharides. Therefore, this paper systematically summarizes the structural characteristics, mechanisms of hypoglycemic action and influence factors of hypoglycemic activity of pumpkin polysaccharides, and looks forward to its research direction and application prospects, and proposes the suggestions, with a view to providing reference for the subsequent research of pumpkin polysaccharides on diabetes.