Abstract: To understand the contamination and antibiotic resistance of Proteus mirabilis in raw meat, a total of 579 samples of pork, chicken, and duck meats were collected from 5 markets, and P. mirabilis in the samples was isolated and identified. The susceptibility to 21 antibiotics of the P. mirabilis isolated in this study was tested by the disk diffusion method. A total of 490 P. mirabilis in those 579 samples were isolated and identified. The contamination rates of P. mirabilis in pork, chicken, and duck meats were 65.61%, 78.95%, and 67.90%, respectively. Market 5 had the highest contamination rate (82.00%) among the chicken samples. The antibiotic resistance rates of all P. mirabilis isolates to erythromycin was the highest, which was higher than 97.85% in all markets, followed by trimethoprim (78.00%~93.68%), doxycycline (73.12%~79.82%), spectinomycin (65.26%~88.17%), tetracycline (64.52%~79.95%), streptomycin (60.55%~86.02%), trimethoprim-sulfameth (52.29%~87.10%), and gentamicin (51.61%~76.15%), all of which were more than 50.00%. The multiple-drug resistance of 490 strains of P. mirabilis was severe with a rate of 100.00%. P. mirabilis strains with pan drug-resistance to all 8 classes of antibiotics accounted for 14.90%. In conclusion, the fresh meats from 5 markets were seriously contaminated by P. mirabilis, and all the isolates had multiple-drug resistance. The contamination and antibiotic resistance of P. mirabilis in this area should be continuously monitored in order to provide more information for the prevention and control of food poisoning and the selection of clinical medication.