Abstract: Bisphenol compounds (BPs) are one of the most significant raw materials, used in synthesizing high polymer materials. At present, common BPs mainly include bisphenol A, bisphenol B, bisphenol F, bisphenol AF and so on. Nowadays, BPs are principally applied in plastic products, the food packaging, drinking water additives, seafood and other fields. A large number of studies have found that BPs penetrate into human beings and animals by physical migration, chemical migration, biological migration and it even have been detected in deep-sea mammals, affecting the mechanisms of the reproductive system, central nervous system, digestive system, cardiovascular system, behavior, development, and metabolic diseases. Therefore, BPs have been attracting more attention. In the review, the classification, invasive pathway to foods of BPs, and its implication on human beings and animals are systematically reviewed, hoping to provide reference for the safety and toxicological evaluation of BPs.