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中国精品科技期刊2020
赵嘉妮,陈宏,翁凌,等. 食源性DPP-IV抑制肽降血糖作用机制研究进展[J]. 食品工业科技,2021,42(23):447−454. doi: 10.13386/j.issn1002-0306.2021010002.
引用本文: 赵嘉妮,陈宏,翁凌,等. 食源性DPP-IV抑制肽降血糖作用机制研究进展[J]. 食品工业科技,2021,42(23):447−454. doi: 10.13386/j.issn1002-0306.2021010002.
ZHAO Jiani, CHEN Hong, WENG Ling, et al. Research Progress on the Mechanism of Food-derived DPP-IV Inhibitory Peptides for Hypoglycemic Effect[J]. Science and Technology of Food Industry, 2021, 42(23): 447−454. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021010002.
Citation: ZHAO Jiani, CHEN Hong, WENG Ling, et al. Research Progress on the Mechanism of Food-derived DPP-IV Inhibitory Peptides for Hypoglycemic Effect[J]. Science and Technology of Food Industry, 2021, 42(23): 447−454. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021010002.

食源性DPP-IV抑制肽降血糖作用机制研究进展

Research Progress on the Mechanism of Food-derived DPP-IV Inhibitory Peptides for Hypoglycemic Effect

  • 摘要: 随着全球糖尿病患者人数的逐年增加,传统的药物治疗方法面临严峻挑战。研究发现,饮食干预是辅助治疗糖尿病的一种有效手段。食物中的蛋白质经酶解后可产生多种生物活性肽。其中,与糖尿病防治密切相关的二肽基肽酶-IV(Dipeptidyl peptidase-IV, DPP-IV)抑制肽已从鱼类等多种食物的酶解液中被发现。海洋生物种类丰富,是制备功能性食品的重要原料来源。本文综述了食源性DPP-IV抑制肽降糖的作用机制,特别是海洋生物来源的DPP-IV抑制肽的研究进展,旨在为开发基于DPP-IV抑制肽的功能性食品提供参考。

     

    Abstract: With the annual increase of diabetes patients all around the world, traditional treatment methods are encountering challenges. Research has found that dietary intervention is an effective way of adjuvant treatment of diabetes. Proteins in food can produce various bioactive peptides after enzymatic hydrolysis. Among them, dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides, which are closely related to the hypoglycemic effect have been identified in enzymatic hydrolysis of fish and other foods. Marine organism is rich in species and they are important resources for preparation of functional foods. In this manuscript, the hypoglycemic mechanism of food-derived DPP-IV inhibitory peptides and the research progress of DPP-IV inhibitory peptides derived from marine organism were reviewed, with a purpose to provide a reference for the development of functional foods based on DPP-IV inhibitory peptides.

     

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