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中国精品科技期刊2020
丁丽娜,王志斌,王瑶,等. 维生素C防治2型糖尿病研究进展[J]. 食品工业科技,2021,42(15):372−376. doi: 10.13386/j.issn1002-0306.2020070147.
引用本文: 丁丽娜,王志斌,王瑶,等. 维生素C防治2型糖尿病研究进展[J]. 食品工业科技,2021,42(15):372−376. doi: 10.13386/j.issn1002-0306.2020070147.
DING Lina, WANG Zhibin, WANG Yao, et al. Research Progress on the Utilization of Vitamin C Against Type 2 Diabetes[J]. Science and Technology of Food Industry, 2021, 42(15): 372−376. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070147.
Citation: DING Lina, WANG Zhibin, WANG Yao, et al. Research Progress on the Utilization of Vitamin C Against Type 2 Diabetes[J]. Science and Technology of Food Industry, 2021, 42(15): 372−376. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070147.

维生素C防治2型糖尿病研究进展

Research Progress on the Utilization of Vitamin C Against Type 2 Diabetes

  • 摘要: 2型糖尿病(T2DM)是由胰岛素缺乏和胰岛素抵抗引起的复杂代谢紊乱性疾病。维生素C(VC)是人体必需的营养素,是众所周知的抗氧化剂,可保护细胞免受氧化应激的伤害。T2DM患者的氧化应激状态对并发症的发生发展起重要作用,适量补充VC可降低T2DM的发病风险。VC与T2DM及其并发症密切相关,T2DM患者血浆VC水平普遍偏低,且血浆VC水平与T2DM的患病风险呈负相关;补充VC可以改善胰岛素抵抗、改善炎症状态,同时可延缓糖尿病肾病的发生发展和心血管的发生风险,但在糖尿病牙周疾病方面并没有明显的改善作用。本文对VC与T2DM发生发展中的作用予以综述,旨在为T2DM的防治提供一定的参考。

     

    Abstract: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder caused by insulin deficiency and insulin resistance.Vitamin C (VC) is an essential nutrient for human body. Vc is an antioxidant to protect cells from oxidative stress. Oxidative stress state played an important role in the occurrence and development of T2DM and its complications. Appropriate supplementation of VC can reduce the risk of T2DM and complications. Recent studies has shown that VC is closely related to the occurrence of T2DM and its complications. The evidence is that plasma VC levels are generally low in patients with T2DM and inversely associated with the risk of T2DM. Supplementation of VC in T2DM patients can improve insulin resistance and inflammation, and also reduce the risk of diabetic nephropathy and cardiovascular disease, but there is no significant improvement in diabetic periodontal disease. This paper summarizes the role of VC in the occurrence and development of T2DM and its complications, with the purpose of providing reference for the prevention and treatment of T2DM.

     

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