雨生红球藻破壁孢子粉对Ⅱ型糖尿病大鼠肝肾的保护作用

毕萃萃 刘银路 杨丽涛 魏芬芬 李勇超 张波

毕萃萃, 刘银路, 杨丽涛, 魏芬芬, 李勇超, 张波. 雨生红球藻破壁孢子粉对Ⅱ型糖尿病大鼠肝肾的保护作用[J]. 食品工业科技, 2021, 42(1): 328-333. doi: 10.13386/j.issn1002-0306.2020020325
引用本文: 毕萃萃, 刘银路, 杨丽涛, 魏芬芬, 李勇超, 张波. 雨生红球藻破壁孢子粉对Ⅱ型糖尿病大鼠肝肾的保护作用[J]. 食品工业科技, 2021, 42(1): 328-333. doi: 10.13386/j.issn1002-0306.2020020325
BI Cui-cui, LIU Yin-lu, YANG Li-tao, WEI Fen-fen, LI Yong-chao, ZHANG Bo. Protective Effects of Sporoderm-broken Spore Powder of Haematococcus pluvialis on Liver and Kidney of Type 2 Diabetes Rats[J]. Science and Technology of Food Industry, 2021, 42(1): 328-333. doi: 10.13386/j.issn1002-0306.2020020325
Citation: BI Cui-cui, LIU Yin-lu, YANG Li-tao, WEI Fen-fen, LI Yong-chao, ZHANG Bo. Protective Effects of Sporoderm-broken Spore Powder of Haematococcus pluvialis on Liver and Kidney of Type 2 Diabetes Rats[J]. Science and Technology of Food Industry, 2021, 42(1): 328-333. doi: 10.13386/j.issn1002-0306.2020020325

雨生红球藻破壁孢子粉对Ⅱ型糖尿病大鼠肝肾的保护作用

doi: 10.13386/j.issn1002-0306.2020020325
详细信息
    作者简介:

    毕萃萃(1994-),女,硕士研究生,研究方向:生物活性物质的功能与毒理,E-mail:1923769549@qq.com。

    通讯作者:

    张波(1962-),女,博士,教授,研究方向:生物活性物质的功能与毒理,E-mail:zhangbo_wl@buu.edu.cn。

  • 中图分类号: TS

Protective Effects of Sporoderm-broken Spore Powder of Haematococcus pluvialis on Liver and Kidney of Type 2 Diabetes Rats

  • 摘要: 目的:研究雨生红球藻破壁孢子粉对Ⅱ型糖尿病大鼠肝肾的保护作用。方法:将SD大鼠随机分为正常组和造模组,正常组以普通饲料喂养,造模组70只大鼠采用高脂高糖饲料饲养4周后,腹腔注射一次链脲佐菌素(STZ)35 mg/kg BW;继续饲养4周,测血糖将造模成功大鼠再分为模型组、低剂量组、中剂量组、高剂量组、降糖药物组(模型组灌胃蒸馏水,低、中、高三个剂量组分别给予50、100和200 mg/kg BW的雨生红球藻破壁孢子粉,降糖药物组给予28.5 mg/kg BW的盐酸二甲双胍),连续干预4周,处死大鼠;测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)活性以及白蛋白(ALB)和球蛋白(GLO)含量,测定肝肾组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量以及肿瘤坏死因子(TNF-α)、白介素1β(IL-1β)水平;制作肝肾HE染色病理切片,观察病理学变化。结果:高剂量雨生红球藻破壁孢子粉可极显著降低糖尿病大鼠血清ALT、AST、ALP、LDH活性和GLO含量(P<0.01),显著减少ALB含量(P<0.05);极显著提高肝肾组织中SOD和GSH-Px活性(P<0.01),极显著降低MDA含量(P<0.01);极显著降低肝肾组织TNF-α和IL-1β水平(P<0.01)。雨生红球藻破壁孢子粉对肝肾组织的损伤有一定的缓解作用。结论:雨生红球藻破壁孢子粉可减轻糖尿病大鼠的肝肾损伤,机制可能与降低氧化应激和炎性反应有关。
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  • 收稿日期:  2020-03-02

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