The effects of pomegranate peel polyphenols(PPP) on the regulation of blood glucose and kidney antioxidant defense function in diabetic mice(DM) were studied in this paper. The diabetic mice were fed with low,medium,high doses of PPP for 6 weeks,the blood glucose,body weight and the kidney antioxidant ability were observed. The results indicated that the PPP could reduce blood glucose levels effectively in diabetic mice,which with no significant difference in body weight. Compared with the DM group,the MDA,NO and GSH-Px in the PPP fed mice were reduced,the CAT and GSH were increased(p<0.05 or p<0.01),but there was no statistical significance in the NOS,SOD and GST of the PPP fed mice(p>0.05). The conclusion was that the PPP had the functions of regulating blood glucose and reduced the oxidative stress of kidney in diabetic mice,which strengthened the kidney antioxidant capacity.